D-Cycloserine Facilitates Extinction of Naloxone-Induced Conditioned Place Aversion in Morphine-Dependent Rats
نویسندگان
چکیده
منابع مشابه
Reversal Effect of Intra-Central Amygdala Microinjection of L-Arginine on Place Aversion Induced by Naloxone in Morphine Conditioned Rats
Background: Role of nitric oxide (NO) on expression of morphine conditioning using a solely classic task has been proposed previously. In this work, the involvement of NO on the expression of opioid-induced conditioning in the task paired with an injection of naloxone was investigated. Methods: Conditioning was established in adult male Wistar rats (weighing 200-250 g) using an unbiased procedu...
متن کاملd-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference.
d-Cycloserine, a partial NMDA agonist, significantly accelerated extinction of a cocaine-induced conditioned place preference (CPP) when rats were given systemic injections immediately, but not 4h, after each extinction trial. Infusions directly into the basolateral amygdala had a similar effect. The facilitative effect of d-cycloserine on the extinction of appetitive conditioning is consistent...
متن کاملBlockade of the Naloxone-induced Aversion in Morphine-conditioned Wistar Rats by L-Arginine Intra-central Amygdala
Objective(s) Single injection of naloxone, a selective antagonist of morphine, prior to the drug conditioning testing was used to investigate on morphine dependence. Materials and Methods Conditioning to morphine (2.5-10 mg/kg, s.c.) was established in adult male Wistar rats (weighing 200-250 g) using an unbiased procedure. Nitric oxide agents were microinjected into the central amygdala pri...
متن کاملreversal effect of intra-central amygdala microinjection of l-arginine on place aversion induced by naloxone in morphine conditioned rats
background: role of nitric oxide (no) on expression of morphine conditioning using a solely classic task has been proposed previously. in this work, the involvement of no on the expression of opioid-induced conditioning in the task paired with an injection of naloxone was investigated. methods: conditioning was established in adult male wistar rats (weighing 200-250 g) using an unbiased procedu...
متن کاملD-cycloserine facilitates extinction of cocaine self-administration in rats.
Previous research has indicated that D-cycloserine [DCS; a N-methyl-D-aspartate (NMDA) partial agonist] facilitates the extinction of conditioned fear as well as the extinction of cocaine conditioned place preference. Sprague Dawley rats were first trained to self-administer cocaine and then we compared their extinction behavior (lever pressing) following treatment with vehicle; 15 mg/kg DCS; o...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2010
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2009.08.015